SBE 13 hydrochloride ( SBE13; SBE 13; SBE13; SBE-13 HCl )

Catalog No. M17781 CAS No. 1052532-15-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

SBE 13 hydrochloride
Note

Research use only, not for human use.
Brief Description

SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.
Description

SBE-13 is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μ M for PLK1, PLK3 and PLK2 respectively).
Synonyms

SBE13; SBE 13; SBE13; SBE-13 HCl
Pathway

Others
Target

Other Targets
Recptor

PLK1; PLK2; PLK3
Research Area

Cancer
Indication

——

CAS Number

1052532-15-6
Formula Weight

479.4
Molecular Formula

C24H28Cl2N2O4
Purity

98%
Solubility

DMSO : ≥ 42 mg/mL; 87.61 mM
SMILES

Clc1ncc(COc2c(OC)cc(CNCCc3cc(OC)c(OC)cc3)cc2)cc1.Cl
Chemical Name

N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine hydrochloride

1. Keppner S, et al. ChemMedChem. 2009 Nov;4(11):1806-9.2. Lange L, et al. Oncotarget. 2014 Apr 30;5(8):2263-75.

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