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SBE 13 hydrochloride

CAS No. 1052532-15-6

SBE 13 hydrochloride ( SBE13; SBE 13; SBE13; SBE-13 HCl )

Catalog No. M17781 CAS No. 1052532-15-6

SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SBE 13 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.
  • Description
    SBE-13 is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μ M for PLK1, PLK3 and PLK2 respectively).
  • Synonyms
    SBE13; SBE 13; SBE13; SBE-13 HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PLK1; PLK2; PLK3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1052532-15-6
  • Formula Weight
    479.4
  • Molecular Formula
    C24H28Cl2N2O4
  • Purity
    98%
  • Solubility
    DMSO : ≥ 42 mg/mL; 87.61 mM
  • SMILES
    Clc1ncc(COc2c(OC)cc(CNCCc3cc(OC)c(OC)cc3)cc2)cc1.Cl
  • Chemical Name
    N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Keppner S, et al. ChemMedChem. 2009 Nov;4(11):1806-9.2. Lange L, et al. Oncotarget. 2014 Apr 30;5(8):2263-75.
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